Single-cell measurement of red blood cell oxygen affinity
نویسندگان
چکیده
منابع مشابه
Single-cell measurement of red blood cell oxygen affinity.
Oxygen is transported throughout the body by hemoglobin (Hb) in red blood cells (RBCs). Although the oxygen affinity of blood is well-understood and routinely assessed in patients by pulse oximetry, variability at the single-cell level has not been previously measured. In contrast, single-cell measurements of RBC volume and Hb concentration are taken millions of times per day by clinical hemato...
متن کاملRed cell 2,3-diphosphoglycerate and oxygen affinity.
The ease with which haemoglobin releases oxygen to the tissues is controlled by erythrocytic 2,3-diphosphoglycerate (2,3-DPG) such that an increase in the concentration of 2,3-DPG decreases oxygen affinity and vice versa. This review article describes the synthesis and breakdown of 2,3-DPG in the Embden-Meyerof pathway in red cells and briefly explains the molecular basis for its effect on oxyg...
متن کاملEffect of Thyroid Dysfunctions on Blood Cell Count and Red Blood Cell Indice
Abstract Background Thyroid hormones have a crucial role in metabolism and proliferation of blood cells. Thyroid dysfunction induces different effects on blood cells such as anemia, erythrocytosis leukopenia, thrombocytopenia, and in rare cases causes’ pancytopenia. It also alter RBC indices include MCV, MCH, MCHC and RDW. Thus this study attempted to evaluate effect of hypo & hyperthyroi...
متن کاملOxygen Affinity of Hemoglobin and Red Cell Acid Base Status
This volume is the publication of the proceedings of the symposium held in May of 1971. Most of the chapters are relatively brief contributions, often by major authorities. The topics discussed include the interaction between hemoglobin and oxygen, carbon dioxide, the red cell membrane, carbonic anhydrase, the regulation of intermediary metabolism of the red cell and of the oxygen affinity of h...
متن کاملRed blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging
Red Blood Cells (RBCs) need to deform and squeeze through narrow capillaries. Decreased deformability of RBCs is, therefore, one of the factors that can contribute to the elimination of aged or damaged RBCs from the circulation. This process can also cause impaired oxygen delivery, which contributes to the pathology of a number of diseases. Studies from our laboratory have shown that oxidative ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1509252112